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Patrick J Casey Selected Research

protein-S-isoprenylcysteine O-methyltransferase

1/2020Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal.
1/2017Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.
3/2016Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia.
9/2014An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo.
5/2013Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).
10/2011A role for Rac3 GTPase in the regulation of autophagy.
3/2005A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

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Patrick J Casey Research Topics

Disease

34Neoplasms (Cancer)
01/2022 - 01/2002
11Carcinogenesis
05/2013 - 10/2004
7Breast Neoplasms (Breast Cancer)
10/2016 - 07/2002
7Neoplasm Metastasis (Metastasis)
01/2016 - 05/2006
6Prostatic Neoplasms (Prostate Cancer)
11/2019 - 03/2005
4Inflammation (Inflammations)
08/2009 - 01/2005
3Insulinoma
05/2010 - 07/2005
3Ischemia
08/2009 - 01/2005
2Insulin Resistance
06/2014 - 02/2008
2Type 2 Diabetes Mellitus (MODY)
06/2012 - 02/2008
1Tics (Tic)
01/2018
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2017
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
03/2016
1Liver Neoplasms (Liver Cancer)
09/2014
1Obesity
06/2014
1Chronic Pain
01/2014
1Epilepsy (Aura)
01/2014
1Schizophrenia (Dementia Praecox)
01/2014
1Glucose Intolerance
06/2012
1Hypertrophy
05/2010
1Multiple Sclerosis
07/2009
1Atherosclerosis
07/2009
1Glaucoma
06/2008
1Lung Neoplasms (Lung Cancer)
05/2007
1Leukemia
05/2005
1Colonic Neoplasms (Colon Cancer)
03/2005

Drug/Important Bio-Agent (IBA)

26Proteins (Proteins, Gene)FDA Link
01/2022 - 07/2002
7protein-S-isoprenylcysteine O-methyltransferaseIBA
01/2020 - 03/2005
7EnzymesIBA
01/2017 - 12/2004
6Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA
01/2014 - 05/2006
5geranylgeranyltransferase type-I (protein geranylgeranyltransferase)IBA
01/2016 - 10/2004
4GTP-Binding Proteins (G-Protein)IBA
01/2022 - 03/2013
4Biological ProductsIBA
08/2019 - 06/2007
4cysmethynilIBA
09/2014 - 03/2005
3Poly(ADP-ribose) Polymerase InhibitorsIBA
12/2021 - 07/2006
3G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2018 - 03/2013
3Monomeric GTP-Binding ProteinsIBA
01/2017 - 06/2009
3ras ProteinsIBA
09/2014 - 12/2004
3Insulin (Novolin)FDA Link
06/2014 - 02/2008
3Poly Adenosine Diphosphate RiboseIBA
08/2009 - 01/2005
3N- (oxo- 5,6- dihydrophenanthridin- 2- yl)- N,N- dimethylacetamide hydrochlorideIBA
08/2009 - 01/2005
3Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
08/2009 - 01/2005
2LigandsIBA
11/2019 - 03/2013
2Biomarkers (Surrogate Marker)IBA
01/2018 - 03/2015
2Messenger RNA (mRNA)IBA
04/2017 - 03/2015
2Small Interfering RNA (siRNA)IBA
01/2017 - 01/2011
2Guanine NucleotidesIBA
06/2014 - 03/2005
2Terpenes (Terpenoids)IBA
07/2011 - 10/2004
2Glucose (Dextrose)FDA LinkGeneric
05/2010 - 02/2008
2Saline SolutionIBA
08/2009 - 01/2005
2Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA
09/2006 - 05/2005
2p21(ras) farnesyl-protein transferase (protein farnesyltransferase)IBA
04/2005 - 10/2004
2Farnesyltranstransferase (Farnesyltransferase)IBA
10/2003 - 01/2002
1AgarIBA
02/2021
1ChemokinesIBA
11/2019
1Adenylate KinaseIBA
01/2019
1Metformin (Glucophage)FDA LinkGeneric
01/2019
1Peptide Hydrolases (Proteases)FDA Link
10/2016
1Kallikreins (Kallikrein)IBA
10/2016
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
03/2016
1Tyrosine Kinase InhibitorsIBA
03/2016
1MicroRNAs (MicroRNA)IBA
03/2015
1indoleIBA
09/2014
1Lamin Type A (Lamin A)IBA
09/2014
1Carrier Proteins (Binding Protein)IBA
06/2014
1Nerve Growth Factors (Neurotrophins)IBA
01/2014
1rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA
01/2014
1Matrix Metalloproteinases (MMPs)IBA
01/2014
1Neurotransmitter Agents (Neurotransmitter)IBA
01/2014
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
01/2014
1InterleukinsIBA
01/2014
1LipidsIBA
07/2011
1Phosphotransferases (Kinase)IBA
01/2011
1Mitogen-Activated Protein KinasesIBA
01/2011
1TOR Serine-Threonine KinasesIBA
05/2010
1Ribosomal Protein S6IBA
05/2010
1Wnt ProteinsIBA
11/2009
1LipopolysaccharidesIBA
08/2009
1RNA (Ribonucleic Acid)IBA
08/2009
1TransferasesIBA
07/2008
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
07/2008
1beta CateninIBA
01/2008
1Adenosine Diphosphate Ribose (ADP-Ribose)IBA
07/2006
1Adenosine Diphosphate (ADP)IBA
07/2006
1ThrombinFDA Link
05/2006
1CalciumIBA
05/2006
1GGTI-DU40IBA
05/2006
1Adenosine Triphosphate (ATP)IBA
07/2005
1PhosphoproteinsIBA
07/2005
1Rho Guanine Nucleotide Exchange FactorsIBA
05/2005
1JNK Mitogen-Activated Protein KinasesIBA
05/2005
1Androgen Receptors (Androgen Receptor)IBA
03/2005
1AndrogensIBA
03/2005
1Epidermal Growth Factor (EGF)IBA
03/2005
1Eosine Yellowish-(YS) (Eosin)IBA
01/2005
1CytokinesIBA
01/2005
1Hematoxylin (Haematoxylon)IBA
01/2005
1Lipid AIBA
10/2004

Therapy/Procedure

8Therapeutics
12/2021 - 03/2005
2Drug Therapy (Chemotherapy)
07/2008 - 05/2003